Software management of the LHC Detector Control Systems

The control systems of each of the four Large Hadron Collider (LHC) experiments will contain of the order of 150 computers running the back-end applications. These applications will have to be maintained and eventually upgraded during the lifetime of the experiments, ~20 years. This paper presents the centralized software management strategy adopted by the Joint COntrols Project (JCOP) [1], which is based on a central database that holds the overall system configuration. The approach facilitates the integration of different parts of a control system and provides versioning of its various software components. The information stored in the configuration database can eventually be used to restore a computer in the event of failure

Crystal Structure of Imaginal Disc Growth Factor-2

Imaginal disc growth factor-2 (IDGF-2) is a member of a recently described family of Drosophila melanogaster-soluble polypeptide growth factors that promote cell proliferation in imaginal discs. Although their precise mode of action has not been established, IDGFs cooperate with insulin in stimulating the growth of imaginal disc cells. We report the crystal structure of IDGF-2 at 1.3-A resolution. The structure shows the classical (betaalpha)(8) barrel-fold of family 18 glycosyl hydrolases, with an insertion of an alpha + beta domain similar to that of Serratia marcescens chitinases A and B. However, amino acid substitutions in the consensus catalytic sequence of chitinases give IDGF-2 a less negatively charged environment in its putative ligand-binding site and preclude the nucleophilic attack mechanism of chitin hydrolysis. Particularly important is the replacement of Glu by Gln at position 132, which has been shown to abolish enzymatic activity in chitinases. Nevertheless, a modest conservation of residues that participate in oligosaccharide recognition suggests that IDGF-2 could bind carbohydrates, assuming several conformational changes to open the partially occluded binding site. Thus, IDGFs may have evolved from chitinases to acquire new functions as growth factors, interacting with cell surface glycoproteins implicated in growth-promoting processes, such as the Drosophila insulin receptor.Fil: Varela, Paloma F.. University of Maryland; Estados UnidosFil: Llera, Andrea Sabina. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Mariuzza, Roy A.. University of Maryland; Estados UnidosFil: Tormo, José. Universidad Autónoma de Madrid; Españ

Toxicidad sobre médula ósea provocada por estrógenos en la especie canina

Desde hace tiempo se conoce que los estrógenos administrados exógenamente o de procedencia endógena pueden provocar un efecto tóxico sobre la médula ósea, especialmente en la especie canina. La toxicidad está en relación con la dosis, los diferentes tipos de estrógenos, la edad del animal y también la distinta sensibilidad individual. La patogénesis de la mielotoxicidad es, en su mayor parte, desconocida. El proceso cursa invariablemente en su inicio con una hiperplasia granulocítica con leucocitosis, neutrofilia y desviación a la izquierda, con trombocitopenia y con anemia progresiva. Finalmente aparece disminución de todas las series hematopoyéticas, con hipoplasia o aplasia medular, que se refleja a nivel de la sangre con leucopenia, trombocitopenia y anemia (pancitopenia). Si bien algunos de los animales afectados pueden recuperarse una vez eliminado el agente causal, son frecuentes los casos en que se desarrolla una aplasia crónica severa e irreversible y el paciente muere debido a anemia profunda, hemorragias masivas por trombocitopenia o infecciones bacterianas secundarias con aparición de cuadros sépticos debido a la neutropema. En el presente artículo revisamos dos casos clínicos de mielotoxicidad por estrógenos, uno después de administración exógena y otro provocado por un hiperestrogenismo asociado a un tumor testicular de células de Sertoli en un macho.It is known for a long time that exogenously administered or endogenous estrogens can provoke a toxic effect on the bone marrow, particularly in the dog. Toxicity is directly correlated with the dose, the different type of estrogens, the animal age, and also the interindividual sensitivity. The pathogenesis of myelotoxicity is mostly unknown. InitiaUy, the process includes invariably a granulocytic hyperplasia and left shifted leukocytosis and neutrophilia foUowed by thrombocytopenia and progressive anemia. FinaUy, it appears a decrease of the whole hematopoietic series with a rnedullar hypoplasia or aplasia which is manifested througb a leukopenia, a thrombocytopenia and an anemia (pancytopenia). Although some of the affected animals can recover once the aethiologic agent is removed, [requently asevere and irreversible chronic aplasia can occur and the patients die due to a deep anemia, thrombocytopenia caused-masive haemorragy, or a secondary bacterial infection with septic clinical signs caused by a neutropenia. The purpose of the present article is to review two cases of estrogen toxicity, both due to exogenous administration and a hyperestrogenism associated to a testicular Sertoli cell tumor in a male

A new clinical tool for assessing numerical abilities in neurological diseases: numerical activities of daily living

The aim of this study was to build an instrument, the numerical activities of daily living (NADL), designed to identify the specific impairments in numerical functions that may cause problems in everyday life. These impairments go beyond what can be inferred from the available scales evaluating activities of daily living in general, and are not adequately captured by measures of the general deterioration of cognitive functions as assessed by standard clinical instruments like the MMSE and MoCA. We assessed a control group (n = 148) and a patient group affected by a wide variety of neurological conditions (n = 175), with NADL along with IADL, MMSE, and MoCA. The NADL battery was found to have satisfactory construct validity and reliability, across a wide age range. This enabled us to calculate appropriate criteria for impairment that took into account age and education. It was found that neurological patients tended to overestimate their abilities as compared to the judgment made by their caregivers, assessed with objective tests of numerical abilities

Maternal short stature does not predict their children's fatness indicators in a nutritional dual-burden sample of urban Mexican Maya.

The co-existence of very short stature due to poor chronic environment in early life and obesity is becoming a public health concern in rapidly transitioning populations with high levels of poverty. Individuals who have very short stature seem to be at an increased risk of obesity in times of relative caloric abundance. Increasing evidence shows that an individual is influenced by exposures in previous generations. This study assesses whether maternal poor early life environment predicts her child's adiposity using cross sectional design on Maya schoolchildren aged 7-9 and their mothers (n = 57 pairs). We compared maternal chronic early life environment (stature) with her child's adiposity (body mass index [BMI] z-score, waist circumference z-score, and percentage body fat) using multiple linear regression, controlling for the child's own environmental exposures (household sanitation and maternal parity). The research was performed in the south of Merida, Yucatan, Mexico, a low socioeconomic urban area in an upper middle income country. The Maya mothers were very short, with a mean stature of 147 cm. The children had fairly high adiposity levels, with BMI and waist circumference z-scores above the reference median. Maternal stature did not significantly predict any child adiposity indicator. There does not appear to be an intergenerational component of maternal early life chronic under-nutrition on her child's obesity risk within this free living population living in poverty. These results suggest that the co-existence of very short stature and obesity appears to be primarily due to exposures and experiences within a generation rather than across generations

AUTOMATING THE CONFIGURATION OF THE CONTROLS SYSTEMS OF THE LHC EXPERIMENTS

The supervisory layer of the Large Hadron Collider (LHC) experiments is based on the Prozeßvisualisierungs- und Steuerungsystem (PVSS) [1] and the Joint COntrols Project (JCOP) Framework (FW) [2]. This controls framework includes a Finite State Machine (FSM) toolkit, which allows to operate the control systems according to a well-defined set of states and commands. During the FSM transitions of the detectors, it is required to re-configure parts of the control systems. All configuration parameters of the devices integrated into the control system are stored in the so-called configuration database. In this paper the JCOP FW FSM-Configuration database tool is presented. This tool ensures the availability of all required configuration data, for a given type of run of the experiment, in the PVSS sub-detector control applications. The chosen implementation strategy is discussed in the paper. The approach enables the standalone operation of different partitions of the detectors simultaneously while ensuring independent data handling

Automating the configuration of the controls systems of the LHC experiments

The supervisory layer of the Large Hadron Collider (LHC) experiments is based on the Prozeßvisualisierungs- und Steuerungsystem (PVSS) [1] and the Joint COntrols Project (JCOP) Framework (FW) [2]. This controls framework includes a Finite State Machine (FSM) toolkit, which allows to operate the control systems according to a well-defined set of states and commands. During the FSM transitions of the detectors, it is required to re-configure parts of the control systems. All configuration parameters of the devices integrated into the control system are stored in the so-called configuration database. In this paper the JCOP FW FSM-Configuration database tool is presented. This tool ensures the availability of all required configuration data, for a given type of run of the experiment, in the PVSS sub-detector control applications. The chosen implementation strategy is discussed in the paper. The approach enables the standalone operation of different partitions of the detectors simultaneously while ensuring independent data handling

Machine learning techniques to select Be star candidates. An application in the OGLE-IV Gaia south ecliptic pole field

Statistical pattern recognition methods have provided competitive solutions for variable star classification at a relatively low computational cost. In order to perform supervised classification, a set of features is proposed and used to train an automatic classification system. Quantities related to the magnitude density of the light curves and their Fourier coefficients have been chosen as features in previous studies. However, some of these features are not robust to the presence of outliers and the calculation of Fourier coefficients is computationally expensive for large data sets. We propose and evaluate the performance of a new robust set of features using supervised classifiers in order to look for new Be star candidates in the OGLE-IV Gaia south ecliptic pole field. We calculated the proposed set of features on six types of variable stars and on a set of Be star candidates reported in the literature. We evaluated the performance of these features using classification trees and random forests along with K-nearest neighbours, support vector machines, and gradient boosted trees methods. We tuned the classifiers with a 10-fold cross-validation and grid search. We validated the performance of the best classifier on a set of OGLE-IV light curves and applied this to find new Be star candidates. The random forest classifier outperformed the others. By using the random forest classifier and colour criteria we found 50 Be star candidates in the direction of the Gaia south ecliptic pole field, four of which have infrared colours consistent with Herbig Ae/Be stars. Supervised methods are very useful in order to obtain preliminary samples of variable stars extracted from large databases. As usual, the stars classified as Be stars candidates must be checked for the colours and spectroscopic characteristics expected for them

Growth and magnetic properties of multiferroic LaxBi1-xMnO3 thin films

A comparative study of LaxBi1-xMnO3 thin films grown on SrTiO3 substrates is reported. It is shown that these films grow epitaxially in a narrow pressure-temperature range. A detailed structural and compositional characterization of the films is performed within the growth window. The structure and the magnetization of this system are investigated. We find a clear correlation between the magnetization and the unit-cell volume that we ascribe to Bi deficiency and the resultant introduction of a mixed valence on the Mn ions. On these grounds, we show that the reduced magnetization of LaxBi1-xMnO3 thin films compared to the bulk can be explained quantitatively by a simple model, taking into account the deviation from nominal composition and the Goodenough-Kanamori-Anderson rules of magnetic interactions

Plasma streams in the Hermean dayside magnetosphere: Solar wind injection through the reconnection region

International audienceThe aim of this research is to simulate the interaction of the solar wind with the magnetic field of Mercury and to study the particle fluxes between the magnetosheath and the planet surface. We simulate the magnetosphere structure using the open source MHD code PLUTO in spherical geometry with a multipolar expansion of the Hermean magnetic field (Anderson, B. J. et al, 2012). We perform two simulations with realistic solar wind parameters to study the properties of a plasma stream originated in the reconnection region between the interplanetary and the Hermean magnetic field. The plasma precipitates along the open magnetic field lines to the planet surface showing a fast expansion, rarefaction and cooling. The plasma stream is correlated with a flattening of the magnetic field observed by MESSENGER due to the adjacency of the reconnection region where the solar wind is injected to the inner magnetosphere